[Diabetes-talk] Pharmacology of Glargine

[Mike Freeman]

MMM ... hafta think about that one.

Mike

----- Original Message ----- 
From: "dmgina" <dmgina at qwest.net>
To: "Diabetes Talk for the Blind" <diabetes-talk at nfbnet.org>
Sent: Thursday, January 22, 2009 12:44 PM
Subject: Re: [Diabetes-talk] Pharmacology of Glargine


Ok I didn't understand all of this,
can you put it into English for me please?
thanks,

--Dar
www.mypowermall.com/biz/home/5779
Every saint has a past
every sinner has a future

----- Original Message ----- 
From: "Mike Freeman" <k7uij at panix.com>
To: <diabetes-talk at nfbnet.org>
Sent: Wednesday, January 21, 2009 7:26 PM
Subject: [Diabetes-talk] Pharmacology of Glargine


> Hi, everyone!
>
> Yesterday, I was looking at the lantus website, http://www.lantus.com 
> and
> became intrigued by the pharmacology of lantus. This long-lasting 
> basal
> insulin, when injected, has a pH of 4 which makes it mildly acidic. 
> Under
> this circumstance, lantus is water-soluble and thus is injected 
> easily.
> Once under the skin, however, the solution is almost immediately
> nutralized (pH of 7) and is no longer water-soluble and thus comes out 
> as
> a precipitate that releases its insulin over the next 24 hours.
>
> My hat is off to whomever came up with this clever notion of how to 
> make a
> long-lasting, peakless insulin. Wish I had that kind of imagination!
>
> Mike Freeman
>
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