<html><head><meta http-equiv="content-type" content="text/html; charset=utf-8"></head><body dir="auto"><blockquote type="cite" style="color: rgb(0, 0, 0);"><div dir="ltr"><div class="hse-body-background" bgcolor="#eaf0f6" style="background-color: rgb(234, 240, 246);"><table role="presentation" class="hse-body-wrapper-table" cellpadding="0" cellspacing="0" width="100%" height="100%" style="border-collapse: collapse; margin: 0px; padding: 0px; width: 337px; height: 2658px; border-spacing: 0px !important; min-width: 320px !important;"><tbody><tr><td class="hse-body-wrapper-td" valign="top" style="border-collapse: collapse; font-family: Helvetica, Arial, sans-serif; font-size: 14px; color: rgb(102, 102, 102); word-break: break-word;"><div id="hs_cos_wrapper_main" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_dnd_area" data-hs-cos-general-type="widget" data-hs-cos-type="dnd_area" style="font-size: inherit; line-height: inherit;"><div id="module_1686846692261" class="hse-section hse-section-last" style="padding-left: 10px; padding-right: 10px; padding-bottom: 20px;"><div class="hse-column-container" style="min-width: 280px; max-width: 600px; width: 317px; margin-left: auto; margin-right: auto; border-collapse: collapse; border-spacing: 0px; padding-top: 20px;"><div id="column_1690993242612_0" class="hse-column hse-size-12"><div id="hs_cos_wrapper_module-14-0-0" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" data-hs-cos-general-type="widget" data-hs-cos-type="module" style="font-size: inherit; line-height: inherit;"><table role="presentation" class="hse-footer hse-secondary" width="100%" cellpadding="0" cellspacing="0" style="border-collapse: collapse; font-family: Arial, sans-serif; font-size: 12px; line-height: 16.200001px; color: rgb(35, 73, 109); margin-bottom: 0px; padding: 0px; border-spacing: 0px !important;"><tbody><tr><td align="center" valign="top" style="border-collapse: collapse; font-family: Helvetica, Arial, sans-serif; font-size: 14px; color: rgb(102, 102, 102); word-break: break-word; text-align: center; margin-bottom: 0px; line-height: 18.9px; padding: 10px 20px;"><p>FYI. I participate. on a regular basis with the.T1D registry to answer questions regarding managing type 1 diabetes. They send out a question every day seeking feedback from real people, and we are under no obligation to answer any particular question. They then use this information for research to better improve treatment and products for treating type 1 diabetes. We are then able to see how other people answer the question and read more detailed explanations from those who chose to contribute additional comments. Participants can also communicate with each other through this net work, and I have learned a lot about how others manage their diabetes in real time. Once a year, they ask you to complete a more detailed questionnaire.</p><p><br></p><p>Patricia</p></td></tr></tbody></table></div></div></div></div></div></td></tr></tbody></table></div></div></blockquote><br><div dir="ltr">Sent from my iPhone</div><div dir="ltr"><br>Begin forwarded message:<br><br></div><blockquote type="cite"><div dir="ltr"><b>From:</b> T1D Exchange Registry <registry@t1dexchange.org><br><b>Date:</b> October 17, 2023 at 9:14:09 AM PDT<br><b>To:</b> pmaddix@comcast.net<br><b>Subject:</b> <b>Milestones in Diabetes Research: 1921 - 2022</b><br><b>Reply-To:</b> registry@t1dexchange.org<br><br></div></blockquote><blockquote type="cite"><div dir="ltr">
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<table role="presentation" cellpadding="0" cellspacing="0" width="100%" style="border-spacing:0 !important; border-collapse:collapse; mso-table-lspace:0pt; mso-table-rspace:0pt"><tbody><tr><td class="hs_padded" style="border-collapse:collapse; mso-line-height-rule:exactly; font-family:Helvetica, Arial, sans-serif; font-size:14px; color:#666666; word-break:break-word; padding:10px 20px 0px"><div id="hs_cos_wrapper_module-10-0-0" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="color: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div id="hs_cos_wrapper_module-10-0-0_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="color: inherit; font-size: inherit; line-height: inherit;" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p style="mso-line-height-rule:exactly; font-size:15px; line-height:150%"><span style="color: #000000;">Research is one of the most reliable ways to answer questions about ourselves and the world around us. Day-to-day, researchers around the globe conduct studies to understand the prevention and treatment of diseases better. Thanks to people like you who contribute valuable time to participating in research studies, researchers and scientists have collected vital data and improved the lives of people with various diseases.</span></p>
<p style="mso-line-height-rule:exactly; font-size:8px; line-height:150%"> </p>
<p style="mso-line-height-rule:exactly; font-size:15px; line-height:150%"><span style="color: #000000;">Research has led to some of the most paramount discoveries in type 1 diabetes (T1D) — from creating new medicines and technologies to invaluable resources. Let’s look at some preeminent milestones in diabetes research over the years!</span></p>
<p style="mso-line-height-rule:exactly; font-size:8px; line-height:150%"> </p>
<ul style="mso-line-height-rule:exactly; font-size:15px; line-height:150%">
<li style="mso-line-height-rule:exactly; line-height:150%"><span style="color: #000000;"><strong>1921</strong>: The discovery of<strong> insulin</strong> by Sir Frederick G. Banting, Charles H. Best, and JJR Macleod at the University of Toronto (later purified by James. B. Collip)</span></li>
<li style="mso-line-height-rule:exactly; line-height:150%"><span style="color: #000000;"><strong>1922</strong>: The <strong>first insulin injection</strong> was given to Leonard Thomson, a 14-year-old boy from Toronto. He lived to be 27 years old.</span></li>
<li style="mso-line-height-rule:exactly; line-height:150%"><span style="color: #000000;"><strong>1979</strong>: The first genetically engineered <strong>fully synthetic human insulin</strong> was produced</span></li>
<li style="mso-line-height-rule:exactly; line-height:150%"><span style="color: #000000;"> <strong>1982</strong>: Eli Lilly produced the first commercially available <strong>biosynthetic “human” insulin using E. coli bacteria </strong>–<strong> </strong>under the brand name Humulin</span></li>
<li style="mso-line-height-rule:exactly; line-height:150%"><span style="color: #000000;"> <strong>1996</strong>: Eli Lilly produced the <strong>first analog (fast-acting) insulin</strong> under the brand name Humalog</span></li>
<li style="mso-line-height-rule:exactly; line-height:150%"><span style="color: #000000;"><strong>2002</strong>: The discovery that <strong>CD3-specific antibodies</strong> slow the loss of beta-cell function in T1D</span></li>
<li style="mso-line-height-rule:exactly; line-height:150%"><span style="color: #000000;"><strong>2006</strong>: Progression towards a <strong>stem cell therapy</strong> for diabetes</span></li>
<li style="mso-line-height-rule:exactly; line-height:150%"><span style="color: #000000;"><strong>2014</strong>: First demonstration of the use of a <strong>closed-loop insulin delivery system</strong> in people with T1D</span></li>
<li style="mso-line-height-rule:exactly; line-height:150%"><span style="color: #000000;"><strong>2016</strong>: Improvements in <strong>islet transplantation</strong> were proven through a phase III clinical trial </span></li>
<li style="mso-line-height-rule:exactly; line-height:150%"><span style="color: #000000;"><strong>2022</strong>: Patient achieved <strong>insulin independence</strong> with Vertex’s islet cell stem cell therapy</span></li>
<li style="mso-line-height-rule:exactly; line-height:125%"><span style="color: #000000;"><strong>2022</strong>: Tzield became the <strong>first FDA-approved therapy</strong> to delay the full onset of T1D</span></li>
</ul>
<p style="mso-line-height-rule:exactly; font-size:8px; line-height:125%"> </p>
<p style="mso-line-height-rule:exactly; font-size:15px; line-height:150%"><span style="color: #000000;">Thanks to your participation in the T1D Exchange Registry, we can continue research to enhance and improve life for people with diabetes. </span></p>
<p style="mso-line-height-rule:exactly; font-size:8px; line-height:150%"> </p>
<p style="mso-line-height-rule:exactly; font-size:15px; line-height:150%"><span style="color: #000000;">THANK YOU for your contributions—for giving us your experience, time, and thoughtful expertise as a person affected by T1D. </span><span style="color: #000000;">You are making type 1 diabetes research happen, and we appreciate you!</span></p>
<p style="mso-line-height-rule:exactly; font-size:8px; line-height:150%"> </p></div></div></td></tr></tbody></table>
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<strong style="color:#ffffff;font-weight:bold;text-decoration:none;font-style:normal;">Click Here to Read More about Milestones in Diabetes Research!</strong>
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