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<FONT size=2 face=Tahoma><B>From:</B> Christian Lavedan
[mailto:Christian.Lavedan@vandapharma.com] <BR><B>Sent:</B> Saturday, October
30, 2010 4:59 PM<BR><B>To:</B> Danielsen, Chris<BR><B>Subject:</B>
Daylight-savings time- Chronic sleepiness - Blindness<BR></FONT><BR></DIV>
<DIV></DIV>
<DIV class=Section1>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Dear Chris
Danielsen<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">As daylight-savings time is
approaching, I thought that you may be interested to know about a local TV show
that will discuss chronic sleepiness on Monday, November 1. Dr. Emsellem from
the Center for Sleep & Wake Disorders in Chevy Chase MD will participate in
<A name=OLE_LINK2></A><A name=OLE_LINK1></A>"Let's Talk Live" hosted by Natasha
Barrett and Melanie Hastings (between 11:30am and 12noon, Comcast: channel 28,
RCN: channel 308, Verizon FIOS: channel 8, U.S. Capitol: channel
48).<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">She will discuss chronic sleepiness,
what you need to know year-round and also in the weeks following the shift to
daylight-savings time. <o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">As you know chronic sleepiness is a
particularly serious problem for some individuals who are blind and lack light
sensitivity necessary to reset their "body clock". As a result, people may
develop a condition called Non 24-Hour Sleep Wake Disorder (N24HSWD) where they
experience inconsistent sleep patterns and often have trouble falling and
staying asleep during conventional hours. <o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">I would appreciate if you could help
us raise awareness of this disorder by passing this information to your friends
and the members of your organization. I have attached a fact sheet on N24HSWD
and the announcement of a clinical trial which is currently enrolling subjects
in the Maryland-Virginia-DC area.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Thank you very
much<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Best
regards,<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=3 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 12pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><STRONG><B><FONT size=3
face="Times New Roman"><SPAN style="FONT-SIZE: 12pt">Christian Lavedan,
Ph.D.</SPAN></FONT></B></STRONG><o:p></o:p></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Head of
Discovery<o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Vanda
Pharmaceuticals<o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><st1:Street
w:st="on"><st1:address w:st="on"><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">9605 Medical Center Drive Suite
300</SPAN></FONT></st1:address></st1:Street><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><st1:place w:st="on"><st1:City
w:st="on"><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Rockville</SPAN></FONT></st1:City><FONT
size=2 face=Arial><SPAN style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">, <st1:State
w:st="on">MD</st1:State> <st1:PostalCode w:st="on">20850</st1:PostalCode>,
<st1:country-region
w:st="on">USA</st1:country-region></SPAN></FONT></st1:place><FONT size=2
face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Tel:
240.599.4500</SPAN></FONT><o:p></o:p></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Fax:
301.294.1900<o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT color=purple size=2
face=Arial><SPAN style="FONT-FAMILY: Arial; COLOR: purple; FONT-SIZE: 10pt"><A
title=blocked::http://www.vandapharma.com/
href="http://www.vandapharma.com/">www.vandapharma.com</A><o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=3
face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><o:p> </o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=3
face="Times New Roman"><SPAN style="FONT-SIZE: 12pt"><IMG id=_x0000_i1025
border=0 src="image001.jpg" width=201 height=53><o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=1 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 7.5pt"><o:p> </o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=1 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 7.5pt">****************************************************************************</SPAN></FONT><o:p></o:p></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=1 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 7.5pt">This message, including its
attachments, is company <o:p></o:p></SPAN></FONT></P>
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style="FONT-FAMILY: Arial; FONT-SIZE: 7.5pt">confidential and may contain
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