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15.0pt 7.5pt 15.0pt'><div><div><div><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:15.0pt;font-family:"Helvetica",sans-serif;color:white'>Research Study Opportunity<o:p></o:p></span></b></p></div></div></div></td></tr></table></div></td></tr></table></div><p class=MsoNormal align=center style='text-align:center'><o:p> </o:p></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;min-width: 100%'><tr><td width="100%" valign=top style='width:100.0%;padding:0in 0in 0in 0in'><div><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse'><tr><td valign=top style='padding:0in 0in 0in 0in'><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse'><tr style='height:.75pt'><td width="100%" valign=top style='width:100.0%;padding:0in 0in 7.5pt 0in;height:.75pt'><div><p class=MsoNormal align=center style='text-align:center;mso-line-height-alt:.75pt'><img width=5 height=1 style='width:.0486in;height:.0069in' id="_x0000_i1031" src="https://imgssl.constantcontact.com/letters/images/sys/S.gif"><o:p></o:p></p></div></td></tr></table></div></td></tr></table></div></td></tr></table></div><p class=MsoNormal align=center style='text-align:center'><o:p> </o:p></p><div align=center><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;min-width: 100%'><tr><td valign=top style='background:white;padding:0in 15.0pt 0in 15.0pt'><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse;min-width: 100%'><tr><td width="100%" valign=top style='width:100.0%;background:white;padding:0in 0in 0in 0in'><div><table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width="100%" style='width:100.0%;border-collapse:collapse'><tr><td valign=top style='padding:7.5pt 15.0pt 7.5pt 15.0pt'><div><div><div><p class=MsoNormal><span style='font-size:13.5pt;font-family:"Arial",sans-serif;color:black'>Hello - </span><span style='font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#172B4D'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#172B4D'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='font-size:13.5pt;font-family:"Arial",sans-serif;color:black'>Brigham and Women’s Hospital and Harvard Medical School are conducting a research study to see if the body’s internal ‘clock’ time can be estimated from levels of different ‘biomarkers’ in blood (levels of proteins, lipids, RNA) taken from a single sample. </span><span style='font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#172B4D'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:13.5pt;font-family:"Arial",sans-serif;color:black'> </span><span style='font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#172B4D'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:13.5pt;font-family:"Arial",sans-serif;color:black'>The researchers are interested in studying adult men and women ages 18 to 70 who are totally blind with no perception to light, regardless of their health. The duration of the study will be for five weeks in total. Participants who complete the study will receive $400. </span><span style='font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#172B4D'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:13.5pt;font-family:"Arial",sans-serif;color:black'> </span><span style='font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#172B4D'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:13.5pt;font-family:"Arial",sans-serif;color:black'>To participate, please contact the study coordinator, Arturo Arrona-Palacios, at 617-394-1026 or </span><span style='font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#172B4D'><a href="mailto:BodyClockStudy@research.bwh.harvard.edu" target="_blank"><span style='font-size:13.5pt;font-family:"Arial",sans-serif;color:#36679C'>BodyClockStudy@research.bwh.harvard.edu</span></a></span><span style='font-size:13.5pt;font-family:"Arial",sans-serif;color:black'>. Participation is voluntary and will not impact medical care received at Brigham Health. </span><span style='font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#172B4D'> <o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#172B4D'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='font-size:13.5pt;font-family:"Arial",sans-serif;color:black'>Thank you,</span><span style='font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#172B4D'><o:p></o:p></span></p></div><div><p class=MsoNormal><span style='font-size:10.5pt;font-family:"Helvetica",sans-serif;color:#172B4D'><o:p> </o:p></span></p></div><div><p class=MsoNormal><span style='font-size:13.5pt;font-family:"Arial",sans-serif;color:black'>Massachusetts Commission for the Blind</span><span 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