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<DIV> </DIV>
<DIV style="FONT: 10pt arial">----- Original Message -----
<DIV style="BACKGROUND: #e4e4e4; font-color: black"><B>From:</B> <A
title=Christian.Lavedan@vandapharma.com
href="mailto:Christian.Lavedan@vandapharma.com">Christian Lavedan</A> </DIV>
<DIV><B>To:</B> <A title=gwunder@earthlink.net
href="mailto:gwunder@earthlink.net">gwunder@earthlink.net</A> </DIV>
<DIV><B>Sent:</B> Tuesday, May 18, 2010 2:32 PM</DIV>
<DIV><B>Subject:</B> Research on Blindness and Sleep </DIV></DIV>
<DIV><BR></DIV>
<DIV class=Section1>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Dear Mr.
Wunder<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">I am contacting you because I
believe that some members of the Missouri Division of the National Association
of Blind Students may be interested in learning about our effort to better
understand sleep problems in people who are totally
blind.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">I am from Vanda Pharmaceuticals, a
pharmaceutical company located in <st1:place w:st="on"><st1:City
w:st="on">Rockville</st1:City>, <st1:State w:st="on"><st1:country-region
w:st="on">MD.</st1:country-region></st1:State></st1:place> Vanda is developing
an experimental new medicine to treat the complaint of the sleep/wake cycle
experienced by some individuals with no light perception.
<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">For this reason, we are interested
in learning more about people who have no light perception blindness and the
problems they face with sleep or wakefulness. Below is an announcement about
upcoming sleep studies that some totally blind individuals may be interested
in.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"> <o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">We gladly welcome the opportunity to
talk to you about our plans and to learn more about you and your organization.
We also would appreciate if you could pass this information along to other
individuals in your community who may be interested by this
research.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Sincerely,<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">C.
Lavedan<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">Announcing Upcoming Sleep Studies in Totally Blind
Individuals<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">Are you blind with no light
perception?<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">Do you have problems sleeping or trouble with daytime
sleepiness?<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">Non-24-hour sleep wake disorder occurs in some
individuals who are totally blind and lack the light sensitivity necessary to
reset the “body clock”. This can lead to problems with sleep and/or daytime
excessive sleepiness.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">You can help researchers understand non-24-hour sleep
wake disorder by taking a brief phone survey. In addition, you will have the
opportunity to be informed of upcoming clinical studies recruiting in your
area.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">Survey Participants Need
to:<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">• be over 18 years of age<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">• be blind with no light
perception<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">• have sleep problems and/or daytime
sleepiness<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">Collected information will be kept strictly
confidential.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">For each completed survey, a donation of $25 up to
$50,000 will be made to organizations that support people with
blindness.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">If you want to participate in the survey, please call
toll-free 1-877-708-1936 Monday-Friday between 9:00 AM and 5:00 PM
ET.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 14pt">Thank you!<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><STRONG><B><FONT size=3
face="Times New Roman"><SPAN style="FONT-SIZE: 12pt">Christian Lavedan,
Ph.D.</SPAN></FONT></B></STRONG><o:p></o:p></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Head of
Discovery<o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Vanda
Pharmaceuticals<o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><st1:Street
w:st="on"><st1:address w:st="on"><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">9605 Medical Center Drive Suite
300</SPAN></FONT></st1:address></st1:Street><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><st1:place w:st="on"><st1:City
w:st="on"><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Rockville</SPAN></FONT></st1:City><FONT
size=2 face=Arial><SPAN style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">, <st1:State
w:st="on">MD</st1:State> <st1:PostalCode w:st="on">20850</st1:PostalCode>,
<st1:country-region
w:st="on">USA</st1:country-region></SPAN></FONT></st1:place><FONT size=2
face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Tel:
240.599.4500</SPAN></FONT><o:p></o:p></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Fax:
301.294.1900<o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT color=purple size=2
face=Arial><SPAN style="FONT-FAMILY: Arial; COLOR: purple; FONT-SIZE: 10pt"><A
title=blocked::http://www.vandapharma.com/
href="http://www.vandapharma.com/">www.vandapharma.com</A><o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=3
face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><o:p> </o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=3
face="Times New Roman"><SPAN style="FONT-SIZE: 12pt"><IMG id=_x0000_i1025
border=0 src="cid:2467992700C44053BFD027CC7FB8967A@gary4fd8f0f186" width=201
height=53><o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=1 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 7.5pt"><o:p> </o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=1 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 7.5pt">****************************************************************************</SPAN></FONT><o:p></o:p></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=1 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 7.5pt">This message, including its
attachments, is company <o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=1 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 7.5pt">confidential and may contain
proprietary information.<o:p></o:p></SPAN></FONT></P>
<P style="MARGIN: 0in 0in 0pt" class=MsoPlainText><FONT size=1 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 7.5pt">Any unauthorized distribution of
this message is strictly prohibited</SPAN></FONT><FONT size=1 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 7.5pt"><o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><o:p> </o:p></SPAN></FONT></P></DIV></BODY></HTML>