[nfb-talk] Fw: Drug Prevents Type 2 Diabetes in Majorityof High-Risk Individuals

Steven Johnson blinddog3 at charter.net
Mon Apr 4 22:12:00 UTC 2011


John, I believe you are correct as I did pass this information onto my
Supervisor who is an R.N. and she sent me the actual study she had received
in one of her journals.

Steve


-----Original Message-----
From: nfb-talk-bounces at nfbnet.org [mailto:nfb-talk-bounces at nfbnet.org] On
Behalf Of John Heim
Sent: Monday, April 04, 2011 10:44 AM
To: NFB Talk Mailing List
Subject: Re: [nfb-talk] Fw: Drug Prevents Type 2 Diabetes in Majorityof
High-Risk Individuals

Most likely it was a double blind study, not a longitudinal study so 
socio-economic factors would probably not be an issue.  In a double blind 
study, the participants are selected at random to receive either a drug or a

placebo. Even the doctor doing the study doesn't know which group a 
particular participant is in. It doesn't make it impossible that just by 
chance, everybody who took the drug smokes and therefore the results are 
invalid. But it makes it very unlikely. So what the author of the study does

is to calculate the probability that something like that could have 
happened. Somewhere in the study there would be a statement saying something

like, "There is a 95% probably that our findings are not due to chance."

I doubt the New England Journal of Medicine would publish a study without 
the appropriate safe guards and calculations. There's always a chance that 
the New Englad Journal of Medicine missed something, that the findings 
represent a statistical fluke, or that the researcher  made a mistake or 
cheated. But still, this is a pretty big deal. A study with over 600 
participants is nothing to sneeze at.

----- Original Message ----- 
From: "Mike Freeman" <k7uij at panix.com>
To: "'NFB Talk Mailing List'" <nfb-talk at nfbnet.org>
Sent: Saturday, April 02, 2011 8:31 AM
Subject: Re: [nfb-talk] Fw: Drug Prevents Type 2 Diabetes in Majorityof 
High-Risk Individuals


> It's awfully early to wax rhapsodic about this; 602 people isn't what I
> consider a statistically-significant sample.  Try half a million and I'd 
> be
> more apt to believe it.  Moreover, I wonder to what extent socioeconomic,
> ethnic and other issues were taken into account.  Medical studies are
> notoriously lax when it comes to inclusion of such factors in their
> analysis.
>
> Mike
>
>
> -----Original Message-----
> From: nfb-talk-bounces at nfbnet.org [mailto:nfb-talk-bounces at nfbnet.org] On
> Behalf Of Ed Meskys
> Sent: Saturday, April 02, 2011 6:24 AM
> To: sandy meskys; nfb-talk
> Subject: [nfb-talk] Fw: Drug Prevents Type 2 Diabetes in Majority of
> High-Risk Individuals
>
>
> ----- Original Message ----- 
> From: "Louis Gosselin" <gosselin_louis at MYFAIRPOINT.NET>
> To: <NHBLIND-TALK at LISTSERV.ICORS.ORG>
> Sent: Saturday, April 02, 2011 9:20 AM
> Subject: Drug Prevents Type 2 Diabetes in Majority of High-Risk 
> Individuals
>
>
> Drug Prevents Type 2 Diabetes in Majority of High-Risk Individuals
> 1-Apr-2011
> March 2011 - A pill taken once a day in the morning prevented type 2
> diabetes in
> more than 70 percent of individuals whose obesity, ethnicity and other
> markers
> put
> them at highest risk for the disease, U.S. scientists reported today.
> The team also noted a 31 percent decrease in the rate of thickening of the
> carotid
> artery, the major vessel that supplies blood to the brain. The study, 
> which
> enrolled
> 602 participants through The University of Texas Health Science Center San
> Antonio
> and seven collaborating centers, is described in the New England Journal 
> of
> Medicine
> and has direct implications for the care of 79 million Americans who are
> pre-diabetic.
> "It's a blockbuster study," said senior author Ralph DeFronzo, M.D.,
> professor
> in
> the School of Medicine and chief of the diabetes division at the UT Health
> Science
> Center San Antonio. "The 72 percent reduction is the largest decrease in 
> the
> conversion
> rate of pre-diabetes to diabetes that has ever been demonstrated by any
> intervention,
> be it diet, exercise or medication."
> Multiple-year follow-up
> Dr. eFronzo led the trial of pioglitazone, which is marketed as Actos by
> Takeda
> Pharmaceutical
> Co. Ltd. The Japanese company provided an independent investigator grant 
> to
> Dr.
> DeFronzo
> to conduct the ACT Now study. Some patients were followed for as long as
> four
> years;
> the average follow-up was 2.4 years.
> Pioglitazone is widely used as an insulin sensitizer in patients with type

> 2
> diabetes.
> In the ACT Now study, participants were chosen because of their high risk
> for
> diabetes,
> including obesity, family history and impaired glucose tolerance as
> demonstrated
> by a glucose test.
> "The drug shows outstanding results," said Robert R. Henry, M.D., 
> president,
> medicine
> and science, of the American Diabetes Association. "It is the most
> efficacious
> method
> we have studied to date to delay or prevent the onset of type 2 diabetes."

> A
> study
> co-investigator, Dr. Henry is professor of medicine at the University of
> California,
> San Diego, and chief of the section of endocrinology and diabetes at the 
> VA
> San
> Diego
> Healthcare System.
> Blood vessel damage prevented
> Robert Chilton, D.O., FACC, a UT Health Science Center San Antonio
> cardiologist
> who
> was not involved with the study, said the slowing of carotid artery
> thickness
> indicated
> that the participants' glucose was well controlled, preventing blood 
> vessel
> damage
> that leads to heart attacks, strokes and peripheral vascular disease.
> Individuals who have diabetes have the same high risk of having a first
> heart
> attack
> as do non-diabetic people who already had a heart attack, he noted.
> "The drug was able to postpone conversion to diabetes in 72 percent of
> people,"
> Dr.
> Chilton said. "The only thing that could potentially beat that is the free
> pill
> no
> one seems to be able to take - diet and exercise."
> Insulin resistance
> Type 2 diabetes involves abnormalities with insulin, a hormone secreted by
> beta
> cells
> in the pancreas. Insulin helps the body store and use sugar from food, but
> in
> type
> 2 diabetes the body is insulin resistant, that is, it inefficiently 
> responds
>
> to
> the
> hormone. With time the beta cells in diabetic patients start to die,
> resulting
> in
> less insulin to handle the demands. Levels of the hormone become
> progressively
> lower
> and sugar levels are increased progressively, damaging blood vessels and
> organs.
> Dr. Henry said the ACT Now study highlights the importance of insulin
> resistance
> in the development of type 2 diabetes and how, by treating this 
> resistance,
> the
> beta
> cell secretion of insulin is preserved for a longer period of time.
> Pioglitazone was well tolerated by participants, with weight gain and 
> fluid
> retention
> observed at the dose used in the study. Dr. DeFronzo said those side 
> effects
>
> can
> be mitigated by using a lower dose that works equally well. Pioglitazone
> stimulates
> appetite while at the same time shifting fat around in the body, taking it
> out
> of
> muscle, the liver and beta cells and putting it in subcutaneous fat depots
> under
> the skin where it is inert and not harmful, he said.
> "No drug is perfect," Dr. DeFronzo said. "This particular medication does
> two
> things
> - improves insulin resistance and improves beta cell function, which are 
> the
>
> two
> core defects of diabetes."
> Co-authors and centers: Pioglitazone for Prevention of Diabetes in 
> Impaired
> Glucose
> Tolerance, Ralph A. DeFronzo, M.D.1*, Devjit Tripathy, M.D., Ph.D.1*, Dawn
> C.
> Schwenke,
> Ph.D., M.S.2,3, MaryAnn Banerji, M.D., F.A.C.P.4, George A. Bray, M.D.5,
> Thomas
> A.
> Buchanan, M.D.6, Stephen C. Clement, M.D.7, Robert R. Henry, M.D.8, Howard
> N.
> Hodis,
> M.D.6, Abbas E. Kitabchi, Ph.D., M.D., F.A.C.P., F.A.C.E.9, Wendy J. Mack,
> Ph.D.6,
> Sunder Mudaliar, M.D.8, Robert E. Ratner, M.D., F.A.C.P.10, Ken Williams,
> M.Sc.11,
> Frankie B. Stentz, M.S., Ph.D.9, Nicolas Musi, M.D.1, and Peter D. Reaven,
> M.D.2
> for the ACT NOW Study
> *Both authors contributed equally to the manuscript
> Texas Diabetes Institute and University of Texas Health Science Center, 
> San
> Antonio,
> TX;
> Phoenix VA Health Care System, Phoenix, AZ;
> W.P. Carey School of Business, Arizona State University, Tempe, AZ;
> SUNY Health Science Center at Brooklyn, Brooklyn, NY;
> Pennington Biomedical Research Center/LSU, Baton Rouge, LA;
> University of Southern California Keck School of Medicine, Los Angeles, 
> CA,
> Division of Endocrinology & Metabolism, Georgetown University, Washington,
> DC;
> VA San Diego Healthcare System and University of California at San Diego;
> University of Tennessee, Division of Endocrinology, Diabetes and 
> Metabolism,
> Memphis,
> TN;
> 10 Medstar Research Institute, Hyattsville, MD; 11KenAnCo Biostatistics, 
> San
> Antonio,
> TX
> Source: University of Texas Health Science Center at San Antonio
>
>
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