<html><head><style type="text/css"><!-- DIV {margin:0px;} --></style></head><body><div style="font-size: 24px;color: rgb(0, 0, 0);font-family: Times New Roman;"><br><blockquote style="color: black; padding-left: 5px; font-family: arial,sans-serif; font-size: 10pt; font-style: normal; font-weight: normal; text-decoration: none; margin-left: 0px; border-left-color: rgb(0, 0, 255); border-left-width: 2px; border-left-style: solid;"><timeladyjr@gmail.com><jrhamilton51@earthlink.net><jeannemgates@me.com><ghermine@gmail.com><br>
<br><br><div dir="ltr"><div class="gmail_quote">Received from a friend who gets messages from GDUI. Passing this along for your information in case you know someone who has a dog or you have these breeds.</div><div class="gmail_quote">Judy Hamilton<br>
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<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">July 12, 2018<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">The U.S. Food and Drug Administration is alerting pet
owners and veterinary professionals about reports of canine dilated
cardiomyopathy (DCM) in dogs eating certain pet foods containing peas, lentils,
other legume seeds, or potatoes as main ingredients. These reports are unusual
because DCM is occurring in breeds not typically genetically prone to the
disease. The FDA’s Center for Veterinary Medicine and the Veterinary Laboratory
Investigation and Response Network, a collaboration of government and veterinary
diagnostic laboratories, are investigating this potential
association.<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">Canine DCM is a disease of a dog’s heart muscle and
results in an enlarged heart. As the heart and its chambers become dilated, it
becomes harder for the heart to pump, and heart valves may leak, leading to a
buildup of fluids in the chest and abdomen. DCM often results in congestive
heart failure. Heart function may improve in cases that are not linked to
genetics with appropriate veterinary treatment and dietary modification, if
caught early.<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">The underlying cause of DCM is not truly known, but is
thought to have a genetic component. Breeds that are typically more frequently
affected by DCM include large and giant breed dogs, such as Great Danes, Boxers,
Newfoundlands, Irish Wolfhounds, Saint Bernards and Doberman Pinschers. It is
less common in small and medium breed dogs, except American and English Cocker
Spaniels. However, the cases that have been reported to the FDA have included
Golden and Labrador Retrievers, Whippets, a Shih Tzu, a Bulldog and Miniature
Schnauzers, as well as mixed breeds.<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">Diets in cases reported to the FDA frequently list
potatoes or multiple legumes such as peas, lentils, other “pulses” (seeds of
legumes), and their protein, starch and fiber derivatives early in the
ingredient list, indicating that they are main ingredients. Early reports from
the veterinary cardiology community indicate that the dogs consistently ate
these foods as their primary source of nutrition for time periods ranging from
months to years. High levels of legumes or potatoes appear to be more common in
diets labeled as “grain-free,” but it is not yet known how these ingredients are
linked to cases of DCM. Changes in diet, especially for dogs with DCM, should be
made in consultation with a licensed veterinarian.<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">In the reports the FDA has received, some of the dogs
showed signs of heart disease, including decreased energy, cough, difficulty
breathing and episodes of collapse. Medical records for four atypical DCM cases,
three Golden Retrievers and one Labrador Retriever, show that these dogs had low
whole blood levels of the amino acid taurine. Taurine deficiency is
well-documented as potentially leading to DCM. The Labrador Retriever with low
whole blood taurine levels is recovering with veterinary treatment, including
taurine supplementation, and a diet change. Four other cases of DCM in atypical
dog breeds, a Miniature Schnauzer, Shih Tzu and two Labrador Retrievers, had
normal blood taurine levels. The FDA continues to work with board certified
veterinary cardiologists and veterinary nutritionists to better understand the
clinical presentation of these dogs. The agency has also been in contact with
pet food manufacturers to discuss these reports and to help further the
investigation.<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">The FDA encourages pet owners and veterinary professionals
to report cases of DCM in dogs suspected of having a link to diet by using the
electronic Safety Reporting Portal or calling their state’s FDA Consumer
Complaint Coordinators. Please see the link below about “How to Report a Pet
Food Complaint" for additional instructions.<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">Additional Information<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">• How to Report a Pet Food Complaint<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">• Veterinary Laboratory Investigation and Response Network
(Vet-LIRN)<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText"><u></u><u></u> </p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText"> <u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">Contact FDA<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">240-402-7002<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">240-276-9115 FAX<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">Issued by: FDA, Center for Veterinary
Medicine<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText"><a href="https://maps.google.com/?q=7500+Standish+Place&entry=gmail&source=g" target="_blank">7500 Standish Place</a>, HFV-1<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">Rockville, MD 20855<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">Page Last Updated: 07/12/2018<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">*** End of press release ***<u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText"><u></u><u></u> </p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText">Link to FDA web page related to this topic <a href="https://www.fda.gov/AnimalVeterinary/NewsEvents/CVMUpdates/ucm613305.htm?utm_campaign=7-12-2018-CanineHeartDisease&utm_medium=email&utm_source=Eloqua" target="_blank">https://www.fda.gov/AnimalVete<wbr>rinary/NewsEvents/CVMUpdates/<wbr>ucm613305.htm?utm_campaign=7-<wbr>12-2018-CanineHeartDisease&<wbr>utm_medium=email&utm_source=<wbr>Eloqua</a><u></u><u></u></p>
<p class="m_-2066128515040528403m_2779474958572901867MsoPlainText"><u></u><u></u> </p></div>
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</ghermine@gmail.com></jeannemgates@me.com></jrhamilton51@earthlink.net></timeladyjr@gmail.com></blockquote></div></body></html>