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<DIV dir=ltr class=OutlookMessageHeader align=left><FONT size=2
face=Tahoma>-----Original Message-----<BR><B>From:</B> Brooke Davis
[mailto:Brooke.Davis@vandapharma.com]<BR><B>Sent:</B> Thursday, December 16,
2010 11:14 AM<BR><B>To:</B> cathyj@iglou.com<BR><B>Subject:</B> Follow Up to
Phone call: Information regarding clinical trial for blind individuals with non
24 hour sleep wake disorder<BR><BR></FONT></DIV>
<DIV class=Section1>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Dear
Cathy,<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">It was very nice to talk to you on
the phone today. Thank you for offering to distribute information about the
study we are conducting, which is testing an experimental treatment for
individuals who are blind and suffer from a sleep disorder known as Non-24 Hour
Sleep Wake Disorder, to members of the NFB of Kentucky. I have copied and pasted
the study announcement to the end of this email. I have also attached an
information packet about the disorder to this email. Please feel free to
distribute this information to anyone who would be interested in this
trial.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Below is some additional information
about the trial that you can send around as well:<o:p></o:p></SPAN></FONT></P>
<UL style="MARGIN-TOP: 0in" type=disc>
<LI style="mso-list: l1 level1 lfo3" class=MsoNormal><FONT size=2
face=Arial><SPAN style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">The site will
arrange and cover the cost for all transportation to and from the site for
participants and guardians. Any other requests for travel arrangements (ie.
guide dogs, hotel) will be accommodated. <o:p></o:p></SPAN></FONT>
<LI style="mso-list: l1 level1 lfo3" class=MsoNormal><FONT size=2
face=Arial><SPAN style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">There is
compensation for participation in the trial. <o:p></o:p></SPAN></FONT>
<LI style="mso-list: l1 level1 lfo3" class=MsoNormal><FONT size=2
face=Arial><SPAN style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Please note that
it is possible that some people may report having some light perception, but
also have sleep issues (e.g. trouble falling asleep, trouble staying
asleep, daytime sleepiness, etc.); we would encourage these people to call the
1800 number on the announcement, as it is still possible that they could
qualify for the trial. <o:p></o:p></SPAN></FONT></LI></UL>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"> </SPAN></FONT><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">We really appreciate you helping us
spread the word about this clinical trial. If you have any questions
or concerns, please don’t hesitate to contact me by phone at 240-599-4535 or by
email at <A title=mailto:brooke.davis@vandapharma.com
href="mailto:brooke.davis@vandapharma.com"><FONT
title=mailto:brooke.davis@vandapharma.com color=black><SPAN
title=mailto:brooke.davis@vandapharma.com><SPAN
title=mailto:brooke.davis@vandapharma.com><SPAN style="COLOR: windowtext"><SPAN
title=mailto:brooke.davis@vandapharma.com>brooke.davis@vandapharma.com</SPAN></SPAN></SPAN></FONT></SPAN></A>.
Thanks for all your help.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">STUDY
ANNOUNCEMENT:</SPAN></FONT><o:p></o:p></P>
<P class=MsoNormal><B><FONT size=5 face="Times New Roman"><SPAN
style="FONT-SIZE: 18pt; FONT-WEIGHT: bold">Clinical Research Study
Recruitment<o:p></o:p></SPAN></FONT></B></P>
<P class=MsoNormal><B><FONT size=6 face="Times New Roman"><SPAN
style="FONT-SIZE: 24pt; FONT-WEIGHT: bold"><o:p> </o:p></SPAN></FONT></B></P>
<P class=MsoNormal><B><FONT size=5 face="Times New Roman"><SPAN
style="FONT-SIZE: 18pt; FONT-WEIGHT: bold">Blind individuals with no light
perception needed.<o:p></o:p></SPAN></FONT></B></P>
<P class=MsoNormal><B><FONT size=6 face="Times New Roman"><SPAN
style="FONT-SIZE: 24pt; FONT-WEIGHT: bold"><o:p> </o:p></SPAN></FONT></B></P>
<P class=MsoNormal><FONT size=5 face="Times New Roman"><SPAN
style="FONT-SIZE: 18pt">A local doctor is conducting research to evaluate a new
investigational treatment for insomnia and daytime sleepiness in individuals who
are totally blind.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=5 face="Times New Roman"><SPAN
style="FONT-SIZE: 18pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=5 face="Times New Roman"><SPAN
style="FONT-SIZE: 18pt">Individuals may qualify
who:<o:p></o:p></SPAN></FONT></P>
<P style="MARGIN-LEFT: 0.5in" class=MsoNormal><FONT size=4 face=SymbolMT><SPAN
style="FONT-FAMILY: SymbolMT; FONT-SIZE: 15pt">• </SPAN></FONT><FONT
size=4><SPAN style="FONT-SIZE: 15pt">are between 18 and 75 years of
age<o:p></o:p></SPAN></FONT></P>
<P style="MARGIN-LEFT: 0.5in" class=MsoNormal><FONT size=4 face=SymbolMT><SPAN
style="FONT-FAMILY: SymbolMT; FONT-SIZE: 15pt">• </SPAN></FONT><FONT
size=4><SPAN style="FONT-SIZE: 15pt">are blind with no light
perception<o:p></o:p></SPAN></FONT></P>
<P style="MARGIN-LEFT: 0.5in" class=MsoNormal><FONT size=4 face=SymbolMT><SPAN
style="FONT-FAMILY: SymbolMT; FONT-SIZE: 15pt">• </SPAN></FONT><FONT
size=4><SPAN style="FONT-SIZE: 15pt">have trouble sleeping at night or
experience daytime sleepiness<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=4 face="Times New Roman"><SPAN
style="FONT-SIZE: 15pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=5 face="Times New Roman"><SPAN
style="FONT-SIZE: 18pt">Participants will be compensated for their time and
effort and will receive study medication and study-related medical evaluation at
no cost.<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=5 face="Times New Roman"><SPAN
style="FONT-SIZE: 16pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=5 face="Times New Roman"><SPAN
style="FONT-SIZE: 16pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><B><FONT size=5 face="Times New Roman"><SPAN
style="FONT-SIZE: 18pt; FONT-WEIGHT: bold">For more
information<o:p></o:p></SPAN></FONT></B></P>
<P class=MsoNormal><B><FONT size=5 face="Times New Roman"><SPAN
style="FONT-SIZE: 18pt; FONT-WEIGHT: bold">Call
1-888-389-7033<o:p></o:p></SPAN></FONT></B></P>
<P class=MsoNormal><FONT size=5 face="Times New Roman"><SPAN
style="FONT-SIZE: 18pt">M-F 9:00 AM to 5:00 PM ET<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Kind
Regards,<o:p></o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><STRONG><B><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Brooke
Davis</SPAN></FONT></B></STRONG><o:p></o:p></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Senior
CRA</SPAN></FONT><o:p></o:p></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Vanda Pharmaceuticals Inc.
</SPAN></FONT><o:p></o:p></P>
<P class=MsoNormal><st1:Street w:st="on"><st1:address w:st="on"><FONT size=2
face=Arial><SPAN style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">9605 Medical Center
Drive, Suite 300</SPAN></FONT></st1:address></st1:Street><o:p></o:p></P>
<P class=MsoNormal><st1:place w:st="on"><st1:City w:st="on"><FONT size=2
face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">Rockville</SPAN></FONT></st1:City><FONT
size=2 face=Arial><SPAN style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">, <st1:State
w:st="on">MD</st1:State> <st1:PostalCode
w:st="on">20850</st1:PostalCode></SPAN></FONT></st1:place><o:p></o:p></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt">P:
240-599-4535</SPAN></FONT><o:p></o:p></P>
<P class=MsoNormal><FONT size=3 face="Times New Roman"><SPAN
style="FONT-SIZE: 12pt"><o:p> </o:p></SPAN></FONT></P>
<P class=MsoNormal><FONT size=2 face=Arial><SPAN
style="FONT-FAMILY: Arial; FONT-SIZE: 10pt"><o:p> </o:p></SPAN></FONT></P></DIV></BODY></HTML>