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</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><div><div style='border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in'><p class=MsoNormal><b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'>From:</span></b><span style='font-size:10.0pt;font-family:"Tahoma","sans-serif"'> Outreach Mailbox [mailto:outreachbox@vandapharma.com] <br><b>Sent:</b> Wednesday, September 07, 2011 9:35 AM<br><b>To:</b> kd4ckt@bellsouth.net<br><b>Subject:</b> A Note of Appreciation<o:p></o:p></span></p></div></div><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal align=right style='text-align:right'><span style='font-family:"Tahoma","sans-serif"'> September 7, 2011<o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal><span lang=EN style='font-family:"Tahoma","sans-serif"'>Dear George Stokes,<o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'>On behalf of Vanda and all of those who suffer from Non-24-Hour Sleep-Wake Disorder (N24HSWD or Non-24) we thank you for participating in our sleep survey. Because of your participation we have so far donated more than $23,000 to various national and local organizations that support individuals with blindness. We wish to especially thank those individuals who have expressed interest in our ongoing clinical study. <o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'>The deadline to enroll patients is approaching and we are writing to you now because we want your help to spread the word about this very important research among your friends and colleagues who may be interested. Our research is taking place at 25 locations in the US, and in France and Germany. However, without enough participants, it will be challenging to develop a treatment for Non-24. <o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'>If you know of anyone who may be interested in our research, please refer them to 1-888-389-7033. As a reminder, we have set up a registry and a survey that are available by phone and on the web. Below is the announcement of our study with phone, email and web contact information and eligibility criteria. <o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'>Your efforts are sincerely appreciated. Thank you for your ongoing support. <o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'>Sincerely,<o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'>The Vanda Outreach Team<o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'>P.S. A screen-reader friendly website (<a href="http://www.24sleepwake.com/">www.24sleepwake.com</a>) dedicated to </span><span lang=EN style='font-family:"Tahoma","sans-serif"'>Non-24</span><span style='font-family:"Tahoma","sans-serif"'> is now available. This site contains News and Information, FAQs, and a forum to </span><span lang=EN style='font-family:"Tahoma","sans-serif"'>share your experience with Non-24.</span><span style='font-family:"Tahoma","sans-serif"'><o:p></o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><span style='font-size:12.0pt;font-family:"Tahoma","sans-serif";mso-fareast-language:EN-US'><br clear=all style='page-break-before:always'></span><p class=MsoNormal><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='text-align:justify'><u><span style='font-family:"Tahoma","sans-serif"'>Announcement</span></u><span style='font-family:"Tahoma","sans-serif"'>:<o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:10.0pt;line-height:115%'><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'>Do you ever feel like your sleep patterns are different than the rest of the world? Do you sometimes feel the unwanted urge or need to fall asleep during the day time when you need to be awake? Do you also find that you feel just too wide awake to fall or stay asleep during the night time? If you are blind, this could be due to a real sleep problem related to the lack of light needed to keep your body's internal clock in sync with the day and night cycle. If you or someone you know might be affected, please call 1-888-389-7033 or email </span><span style='font-size:11.0pt;line-height:115%;font-family:"Calibri","sans-serif"'><a href="mailto:info@non24registry.com"><span style='font-family:"Arial","sans-serif"'>info@non24registry.com</span></a></span><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'> to learn about an ongoing clinical research study that is evaluating a new investigational treatment for this type of sleep problem. When calling or online at </span><span style='font-size:11.0pt;line-height:115%;font-family:"Calibri","sans-serif"'><a href="http://www.non24registry.com/"><span style='font-family:"Arial","sans-serif"'>www.non24registry.com</span></a></span><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'>, you can also complete a short sleep survey. For each completed survey, $25 will be donated to an organization that supports individuals with blindness. You may be eligible to participate in the clinical trial if you are between 18 and 75 years of age and are totally blind. Volunteers will be compensated for their participation in the clinical study and will receive study related medication, medical evaluations, and transportation at no cost. <o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:10.0pt;line-height:115%'><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:10.0pt;line-height:115%'><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:10.0pt;line-height:115%'><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:10.0pt;line-height:115%'><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:10.0pt;line-height:115%'><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal align=center style='margin-bottom:10.0pt;text-align:center;line-height:115%'><span style='font-size:8.0pt;line-height:115%;font-family:"Arial","sans-serif";color:black'>We respect your privacy.</span><span style='font-size:8.0pt;line-height:115%;font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p class=MsoNormal align=center style='margin-bottom:10.0pt;text-align:center;line-height:115%'><span style='font-size:8.0pt;line-height:115%;font-family:"Arial","sans-serif";color:black'>If you no longer wish to receive promotional email from Vanda Pharmaceuticals, please send an email to </span><span style='font-size:11.0pt;line-height:115%;font-family:"Calibri","sans-serif"'><a href="mailto:unsubscribe@vandapharmaceuticals.com" target="_blank" title="blocked::mailto:unsubscribe@vandapharmaceuticals.com"><span style='font-size:8.0pt;line-height:115%;font-family:"Arial","sans-serif"'>unsubscribe@vandapharmaceuticals.com</span></a></span><span style='font-size:8.0pt;line-height:115%;font-family:"Arial","sans-serif";color:black'> to let us know. Thank you.</span><span style='font-size:8.0pt;line-height:115%;font-family:"Arial","sans-serif"'><o:p></o:p></span></p><p class=MsoNormal style='margin-bottom:10.0pt;line-height:115%'><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:10.0pt;line-height:115%'><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:10.0pt;line-height:115%'><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:10.0pt;line-height:115%'><span style='font-size:11.0pt;line-height:115%;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:10.0pt;line-height:115%'><span style='font-family:"Tahoma","sans-serif"'><o:p> </o:p></span></p></div></body></html>